When I carry my G22, I have 180 HST in the gun, and Double Tap's 180 Gold Dot in the spare mag.
I do this mainly to have different choices, or if I happen on a situation where I think I might need the extra penetration of the bonded GD I can switch if I have time. I would trust either to tear a car apart on the way through.
Gen 4: 17 (9), 19 (2), 21 (2), 26, 41
You are on your own out there... Act Accordingly.